What is EGF?

The component of EGF was awarded the Nobel prize.

EGF stands for Epidermal Growth Factor, and it was discovered by American biologist Dr. Stanley Cohen. EGF is a polypeptide with 53 amino acids and made of internal proteins. EGF works by stimulating the production of a new cell after it combines with a receptor. EGF plays an important role in restoring damaged epidermal skin and protecting it from toxic substances such as ultraviolet rays (UV light). Dr Cohen was awarded the Nobel prize of medical physiology for this discovery.

Now EGF can be mass-produced outside the body at a factory, and is used for patients with burned skin recuperating after a skin transplantation and cornea recuperating after incision. EGF is expected to be used in the field of esthetic salons. At the first stage, EGF costed 700,000USD per gram. As research proceeds, the cost of production can be cut tremendously. By now, one decade after its discovery, EGF can easily be purchased and used by consumers for skin-care.

EGF is a regenerative factor humans naturally have, but as one ages it naturally decreases. Finally the regeneration of skin becomes dull and skin aging is accelerated. When you supply EGF to the surface of the skin, EGF helps stimulating the regeneration of epidermal skin smoothly. EGF is not absorbed further in case it is saturated in the skin cells. Furthermore you do not need to worry about any side-effects.

Mechanism of regeneration

*EGF combines with specific receptors in epidermal skin.
*EGF transmits a message to skin cell, and controls pH and Ca, then stimulates glycolysis
  and synthesization of protein.
*Copying of DNA starts, leading to increased skin cells.

EGF clinical data and patent in USA
EGF proves regeneration of new skin cells at an average of 284%
Dr. Brown in USA applied cream with EGF (EGF contains 0.1mu gram/ml=0.00001%) to testees of 12 people in a trial (between 32 years old and 62 years old) for 60 days. As a result of this research, it proves tremendous increase of skin cells. The graph shows that the skin cells at each age increase significantly.

Percentage of S-cell (percentage of keratin)

Testee number and age    cream with non-EGF   cream with EGF 0.1 mug/ml

  1.  62 years old             　　　　　　　　1.2                    　　　　　　　9.9
  2.  44 years old             　　　　　　　　4.0                   　　　　　　 10.2
  3.  51 years old             　　　　　　　　3.4                   　　　　　　 12.6
  4.  36 years old             　　　　　　　　5.0                    　　　　　　  8.7
  5.  62 years old             　　　　　　　　1.8                   　　　　　　 15.7
  6.  52 years old             　　　　　　　　3.4                    　　　　　　  8.6
  7.  44 years old             　　　　　　　　6.1                   　　　　　　 11.8
  8.  32 years old             　　　　　　　　7.1                   　　　　　　 10.9
  9.  39 years old             　　　　　　　　5.0                   　　　　　　 13.9
10.  60 years old               　　　　　　　1.4                    　　　　　　  9.8
11.  46 years old              　　　　　　　 3.7                   　　　　　   14.9
12.  36 years old              　　　　　　　 7.8                   　　　　　   15.0
             Average                    　　 4.15                  　　　　　    11.8